To form the cast of Destroy Madrid, director Joseba Alfaro has trusted again in Javier Server for the lead role, with whom he worked in his previous short film REM.

Although the character of Lay is the only one involved in the action, there are a certain number of «characters with minimal appearance» for which the director has decided to rely on his team members —introducing Alberto Rama, Nacho Nava and Patricia Zori, plus two more characters whose names can not be revealed yet.